CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting
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چکیده
منابع مشابه
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thoroughly understood. Here we show that CRY1 is activated by insulin-induced SREBP1c and decreases hepatic gluconeogenesis through FOXO1 degradation, at least, at specific circadian time...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2018
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-018-0538-3